Datura stramonium is an intriguing plant noted for its medical and hallucinogenic qualities, with different species demonstrating a variety of biological activities including antibacterial, antioxidant, and immune response improvement. Secondary metabolites such as terpenoids, flavonoids, and tropane alkaloids—specifically, scopolamine and atropine—are responsible for this. Consuming Jimson marijuana may cause anticholinergic intoxication, which manifests as a set of symptoms. Biopesticides made from Datura stramonium are less expensive, safer, and better for the environment than broad-spectrum conventional pesticides. They can help manage insects that cause postharvest losses, such as weevils. Living microorganisms including cyanobacteria, rhizobium, and azotobacter are found in biofertilizers, which are essential for organic farming since they increase plant growth and improve nutrient availability. All things considered, Datura stramonium has medicinal advantages as well as possible uses in sustainable agriculture.